Note: Research results related to MSTM products are highlighted in blue color

I) SPECIAL JOURNAL ISSUES ON NOVEL IONIZATION PROCESSES IN MASS SPECTROMETRY

A) Amer. J. Am. Soc. Mass Spectrom. honoring the Biemann Award to Sarah Trimpin (in progress)

2)  Austin, C.A., Inutan, E.D., Bohrer, B.C., Li, J., Fischer, J.L., Wijerathne, K., Foley, C.D., Fischer, J.L., Li, J., Foley, C.D., Lietz, D.W., Woodall, D.W., Imperial, L.F., Clemmer, D.E., Trimpin, S., Larsen, B.S. Resolving Isomers of Star-Branched Poly(Ethylene Glycols) from Surfaces by MAI-IMS-MS. J. Am. Soc. Mass Spectrom. DOI: 10.1021/jasms.0c00045

1)  Trimpin, S., Lu, I., Rauschenbach, S., Hoang, K., Wang, B., Chubatyi, N., Zhang, W-J., Inutan, E.D., Pophristic, M., Sidorenko, A., McEwen,C.N. Spontaneous Charge Separation and Sublimation Processes are Ubiquitous in Nature and in Ionization Processes in Mass Spectrometry. J. Am. Soc. Mass Spectrom 2018, DOI: 10.1021/jasms.8b05743

 

B) Rapid Communications in Mass Spectrometry, Guest Editor Trimpin

10) Trimpin, S., Marshall, D.D., Karki, S., Madarshahian, S., Hoang, K., Meher, A.K., Pophristic, M., Richards, A.L., Lietz, C.B., Fischer, J.L., Elia, E.A., Wang, B., Pagnotti, V.S., Lutomski, C.L., El-Baba, T.J., Lu, I-C., Wager-Miller, J., Mackie, K., McEwen, C.N., Inutan, E.D., An Overview of Applications and Fundamentals of New Inlet and Vacuum Ionization Technologies. Rapid Commun. Mass Spectrom. 2020, DOI: 10.1002/rcm.8829

9)  Inutan, E.D., Jarois, D.R., Lietz, C.B., El-Baba, T.J., Elia, E.A., Sampat, A.A.S., Foley, C.D., Clemmer, D.E., Trimpin S., Ubiquitin Ion Structures from the Solid State using Nothing More than a Small Molecule and Vacuum of an IMS-MS Instrument. Rapid Commun. Mass Spectrom. 2020.

8)  Karki, S., Meher, A.K., Inutan, E.D., Pophristic, M., Marshall, D.D., Rackers, K., Trimpin, S., McEwen, C.N., Development of a Robotics Platform for Automated Multi-ionization Methods for Mass Spectrometry. Rapid Commun. Mass Spectrom. 2019, DOI: 10.1002/rcm.8449.

7)  Apsokardu, M.J., Kerecman, D.E., Johnston, M.V., Ion Formation in Droplet Assisted Ionization. Rapid Commun. Mass Spectrom. 2019, DOI: 10.1002/rcm.8227.

6)  Hale, O., Ryumin, P., Brown, J., Morris, M., Cramer, R., Production and Analysis of Multiply Charged Negative Ions by Liquid AP-MALDI MS. Rapid Commun Mass Spectrom. 2019, DOI: 10.1002/rcm.8246.

5)  Li, X., Attanayake, K., Valentine, S.J., Li, P., Vibrating sharp-edge spray ionization (VSSI) for voltage-free direct analysis of samples using mass spectrometry. Rapid Commun. Mass Spectrom. 2019, DOI:10.1002/rcm.8232.

4)  Liyanage, R., Gidden, J., Wilkins, C.L., Lay, J.O. (Jr), MAI-FTMS for the Analysis of Lipids. Rapid Commun. Mass Spectrom. 2019, DOI: 10.1002/rcm.8349.

3)  Chen, YH., Lu, IC., Novel ion source for a portable mass spectrometer. Rapid Commun Mass Spectrom. 2019 DOI: 10.1002/rcm.8503

2)   Lee, C., Inutan, E.D., Chen, J.L., Mukeku, M.M., Weidner, S.M., Trimpin, S., Ni, C.K., Toward Understanding the Ionization Mechanism of Matrix‐Assisted Ionization using Mass Spectrometry Experiment and Theory. Rapid Commun. Mass Spectrom. 2019, DOI: 10.1002/rcm.8382

1) Skjærvø, Ø., Trimpin, S., Halvorsen, T.G., Matrix Assisted Ionization Mass Spectrometry in Targeted Protein Analysis – An Initial Evaluation. Rapid Commun. Mass Spectrom. 2019, DOI: 10.1002/rcm.8437.

II) PUBLICATIONS: Related Fundamental Research by Professors Trimpin and McEwen

A. Book and Book Chapters

5)  Trimpin, S., Wang, B., Inlet and Vacuum Ionization from Ambient Conditions, in: Ambient Ionization Mass Spectrometry. Royal Society of Chemistry, by Eds. Robert Cody and Marek Domin, 2014, pp. 423-444. (DOI: 10.1039/ISBN 978-1-84973-926-9).

4)  McEwen, C.N., Lieu, T., Saylor, S., Twohig, M., Balogh, M.P., Atmospheric Samples Analysis Probe (ASAP) Mass Spectrometry, in: Ambient Ionization Mass Spectrometry. Royal Society of Chemistry, by Eds. Robert Cody and Marek Domin, 2014, pp. 104-119. (DOI: 10.1039/ISBN 978-1-84973-926-9).

3)  Lietz, C.B., Richards, A.L., Marshall, D.D., Ren. Y., Trimpin, S., Matrix Assisted Inlet Ionization and Solvent-free Gas-Phase Separation using Ion Mobility Spectrometry for Imaging and Electron Transfer Dissociation Mass Spectrometry of Polymers, in: Mass Spectrometry in Polymer Chemistry, Wiley-VCH, by Eds. Christopher Barner-Kowollik, Till Gründling, Jana Falkenhagen, and Steffen Weidner, pp. 85–118, 2012.

2) Inutan, E.D., Claude, E., Trimpin, S. Total Solvent-free Analysis, Charge Remote Fragmentation, and Structures of Highly Charged Laserspray Ions using IMS-MS, in: Ion Mobility Spectrometry: Theory and Applications, Taylor and Francis Group, by Eds. Charles L. Wilkins and Sarah Trimpin, pp. 189-214, 2010.

1)  McEwen, C.N., Major, H., Green, M., Giles, K., Trimpin, S. IMS/MS Applied to Direct Ionization using the Atmospheric Solids Analysis Probe Method Ion Mobility Spectrometry, in: Ion Mobility Spectrometry: Theory and Applications, Taylor and Francis Group, by Eds. Charles L. Wilkins and Sarah Trimpin, pp. 171–188, 2010.

C. Invited Review and Other Articles

16) Section on MAI-MS, in undergraduate textbook: Harris “Quantitative Chemical Analysis”, 10th Edition by publisher, W. H. Freeman.  December 2019.

15) Meet the Associate Editors: Sarah Trimpin. Rapid Commun. Mass Spectrom. 33(SI): 24–25, 2019. (Special Issue Highlighting Editorial Board Members)

14) Trimpin, S., Novel Ionization Processes for Use in Mass Spectrometry: ‘Squeezing’ Nonvolatile Analyte Ions from Crystals and Droplets.  Rapid Commun. Mass Spectrom. 33(SI): 96–120, 2019. (Special Issue Highlighting Associate Editors)

  • This paper was selected to be highlighted on the cover page of the journal

13) Trimpin, S., Karki, S., Marshall, D.D., Inutan, E.D., Meher, A.K., Madarshahian, S., Fenner, M.A., McEwen, C.N., Novel and Traditional Ionization Methods for Mass Spectrometry Combined to Provide More Comprehensive Analyses. LCGC North America, 2018, March issue, 35(8), 507–510.

12) Trimpin, S., Redefining Simplicity in Ionization: Discovery and Implementation of Novel Ionization Processes in Mass Spectrometry. LCGC North America, 2017, August issue, Vol. 35, Issue 8, pp. 507–510.

11) Peacock, P.M., Zhang, W.J., Trimpin, S., Advances in Ionization for Mass Spectrometry, Anal. Chem. 89(1): 372−388, 2017.

10) Trimpin, S., Analytical Scientist highlighted In My View (an invited opinion article on MS Technology), 2016, September issue, pages 18–19.

9)  Trimpin, S., Thawoos, S., Lu, I-C., DeLeeuw, J.L., Hoang, K., Devereaux, Z.J., Pophristic, M., Chakrabarty, S., Caruso, J.A., Stemmer, P.M., Narayan, S.B., McEwen, C.N., Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drug and Clinical Analyses. LCGC and Spectroscopy, 2016, May issue, pages 8–19.

8)  Trimpin, S., Wang, B., Lutomski, C.A., El-Baba, T.J., Harless, B.M., A Convenient Alternative to MALDI and ESI, by request of the journal republished in ‘Current Trends in Mass Spectrometry’ (www. spectroscopyonline.com), LCGC and Spectroscopy, 2016, March issue, pages 53–61.

7)  Hassan, L., McEwen, C.N., Solvent Assisted Ionization Mass Spectrometry for Screening and Quantification of Counterfeit Drugs. Spectroscopy. Special Issue, 2015, Volume 13, Issue 3, pp. 8–13.

6)  Trimpin, S., “Magic” Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. 27(1): 4–21, 2016. (invited Critical Insight Article dedicated for controversial topics and established experts in the field)

5)  McEwen, C.N., Larsen, B.S., Fifty years of desorption ionization of nonvolatile compounds. Int. J. Mass Spectrom. 377:515–531, 2015.

4)  Trimpin, S., Chakrabarty, S., Wang, B., Hoang, K., Lutomski, C.A., Inutan, E.D., McEwen, C.N., Non-Conventional Alternatives to LC/MS, LCGC and Spectroscopy, 2015, May issue, pages 22–33.

3)  Trimpin, S., Wang, B., Lutomski, C.A., El-Baba, T.J, Harless, B.M., A Convenient Alternative to MALDI and ESI, in ‘Current Trends in Mass Spectrometry’ (www. spectroscopyonline.com), LCGC and Spectroscopy, 2014, May issue, pages 8–17.

2)  El-Baba, T.J, Lutomski, C.A., Wang, B., Inutan, E.D., Trimpin, S., Toward High Spatial Resolution Sampling and Characterization of Biological Tissue Surfaces using Mass Spectrometry. Anal. Bioanal. Chem. 406(17):4053–4061, 2014. (Review)

1)  Trimpin, S., Wang, B., Lietz, C.B., Marshall, D.D., Richards, A.L., Inutan, E.D., New Ionization Processes and Applications for Use in Mass Spectrometry. Crit. Rev. Biochem. Mol. Biol. 48(5):409–429, 2013. (Review)

C. Peer-Reviewed Research Publications

65)  Inutan, E.D., Jarois, D.R., Meher, A.K., Karki, S., Fischer, J.L., Imperial, L.F., Foley, C.D., El-Baba, T.J., Lutomski, C.L., Trimpin, S., New Concepts for Synthetic Polymers and Additives Characterization. Rapid Commun. Mass Spectrom. 2020, DOI: 10.1002/rcm.8768

64)  Trimpin, S., Inutan, E.D., Karki, S., Elia, E.A., Zhang, W.J., Weidner, S.M., Marshall, D.D., Hoang, K., Lee, C., Davis, E.T.J., Smith, V., Meher, A.K., Cornejo, M., Auner, G.W., McEwen, C.N., Fundamental Studies of New Ionization Technologies and Insights from IMS-MS. J. Am. Soc. Mass Spectrom. 2019, 30, 1133–1147. (Invited contribution to special issue on ‘ion mobility’ in honor of von Helden, Jarrold, Clemmer ASMS Distinguished Contribution Award)

63)  Trimpin, S., Pophristic, M., Adeniji’Adele, A., Tomsho, J.W., McEwen, C.N., Vacuum Matrix-Assisted Ionization Source Offering Simplicity, Sensitivity, and Exceptional Robustness in Mass Spectrometry. Anal. Chem. 90(19): 11188-11192, 2018.

62)  Trimpin, S., Lee, C., Weidner, S.M., El-Baba, T. J., Lutomski, C.A., Inutan, E.D., Foley, C.D., Ni, C.K., McEwen, C.N., Unprecedented Ionization Processes in Mass Spectrometry Provide Missing Link between ESI and MALDI. ChemPhysChem 19(5): 581–589, 2018.

  • This paper was highlighted on the cover page of the journal.

61)  Trimpin, S., Lu, I-C., Rauschenbach, S., Hoang, K., Wang, B., Chubatyi, N.D., Zhang, W.-J., Inutan, E.D., Pophristic, M., Sidorenko, A., McEwen, C.N., Spontaneous Charge Separation and Sublimation Processes are Ubiquitous in Nature and in Ionization Processes in Mass Spectrometry. J. Am. Soc. Mass Spectrom. 29(2): 304–315, 2018. (Invited contribution to special issue on Asilomar Conference)

60)  Madarshahian, S., Pophristic, M., McEwen, C.N., Infrared atmospheric solids analysis probe (IRASAP) mass spectrometry for ambient analysis of volatile compounds without heated gas. Anal. Methods 9(34): 5009-5014, 2017. (Invited contribution to special issue on ambient ionization)

59)  Lu, I-C., Elia, E.A., Zhang, W.-J., Pophristic, M., Inutan, E.D., McEwen, C.N., Trimpin, S., Development of an Easily Adaptable, High Sensitivity Source for Inlet Ionization. Anal. Methods 9(34): 4971–4978, 2017. (Invited contribution to special issue on ambient ionization)

58)  Fenner, M.A., Chakrabarty, S., Wang, B., Pagnotti, V.S., Hoang, K., Trimpin, S., McEwen, C.N., A New LC/MS Method Providing Improved Sensitivity: Electrospray Ionization Inlet. Anal. Chem. 89(9): 4798–4802, 2017.

57)   Lu, I.C., Pophristic, M., Inutan, E.D., McKay, R.G., McEwen, C.N., Trimpin, S., Simplifying the ion source for mass spectrometry. Rapid Commun. Mass Spectrom. 30: 2568–2572, 2016.

56)  Hoang, K., Pophristic, M., Horan, A.J., Johnston, M.V., McEwen, C.N., High Sensitivity Analysis of Nanoliter Volumes of Volatile and Nonvolatile Compounds using Matrix Assisted Ionization (MAI) Mass Spectrometry. J. Am. Soc. Mass Spectrom. 27: 1591–1596, 2016.

55)  Devereaux, Z.J., Reynolds, C.A., Fischer, J.L., Foley, C.D., DeLeeuw, J.L., Wager-Miller, J., Narayan, S.B., Mackie, K., Trimpin, S., Matrix-Assisted Ionization (MAI) on a Portable Mass Spectrometer: Analysis Directly from Biological and Synthetic Materials. Anal. Chem. 88(22): 10831–10836, 2016.

54)  Marshall, D.D., Inutan, E.D., Wang, B., Liu, C.W., Thawoos, S., Wager-Miller, J., Mackie, K., Trimpin, S., A Broad-based Study on Hyphenating New Ionization Technologies with MS/MS for PTM’s and Tissue Characterization. Proteomics 16(11-12): 1695–1706, 2016. (Invited paper)

53)  Trimpin, S., Thawoos, S., Foley, C.D., Woodall, D.W., Li, J., Inutan, E.D., Stemmer, P.M., Rapid High Mass Resolution Mass Spectrometry using Matrix-Assisted Ionization. Methods 104: 63–68, 2016. (Invited paper)

52)  Vithanarachchi, S.M., Foley, C.D., Trimpin, S., Ewing, J.R., Ali, M.M., Allen, M.J., Myelin-specific, multimodal imaging agent for magnetic resonance and optical imaging. Contrast Media & Molecular Imaging 11(6): 492–505, 2016.

51)  Fischer, J.L., Lutomski, C.A., El-Baba, T.J., Siriwardena-Mahanama, B.N., Weidner, S.M., Falkenhagen, J., Allen, M.J., Trimpin, S., Matrix-Assisted Ionization-Ion Mobility Spectrometry-Mass Spectrometry: Selective Analysis of a Europium-PEG Complex in a Crude Mixture. J. Am. Soc. Mass Spectrom. 26(12): 2086–2095, 2015.

50)  Chakrabarty, S., DeLeeuw, J.L., Woodall, D.W., Jooss, K., Narayan, S.B., Trimpin, S., Reproducibility and Quantitation of Illicit Drugs using Matrix-Assisted Ionization (MAI) Mass Spectrometry. Anal. Chem. 87(16): 8301–8306, 2015.

49)  Wang, B., Dearring, C.L., Wager-Miller, J., Mackie, K., Trimpin, S., Drug Detection and Quantification Directly from Tissue using Novel Ionization Methods for Mass Spectrometry. Eur. J. Mass Spectrom. 21(3): 201–210, 2015. (Invited contribution to special 20th Anniversary Issue)

48)  Fenner, M.A., McEwen, C.N., Survival Yield Comparison between ESI and SAII: Mechanistic Implications. Int. J. Mass Spectrom. 378: 107–112, 2015.

47)  Woodall, D.W., Wang, B., Inutan, E.D., Narayan, S.B., Trimpin, S., High-throughput Characterization of Small and Large Molecules Using Only a Matrix and the Vacuum of a Mass Spectrometer. Anal. Chem. 87(9): 4667–4674, 2015.

46)  Chubatyi, N.D., McEwen, C.N., Improving the Sensitivity of Matrix-Assisted Ionization (MAI) Mass Spectrometry Using Ammonium Salts. J. Am. Soc. Mass Spectrom. 26: 1649–1656, 2015.

45)  Trimpin, S., Lutomski, C.A., El-Baba, T.J., Woodall, D.W., Foley, C.D., Manly, C.D., Wang, B., Liu, C.W., Harless, B.M., Kumar, R., Imperial, L.F., Inutan, E.D., Magic Matrices for Ionization in Mass Spectrometry. Int. J. Mass Spectrom. 377(SI): 532–545, 2015. (Invited contribution to 100th year of Mass Spectrometry special issue)

44)  Pagnotti, V.S, Chakrabarty, S., Wang, B., Trimpin, S., McEwen, C.N., Gas-Phase Ions Produced by Freezing Water or Methanol for Analysis Using Mass Spectrometry. Anal. Chem. 86(15): 7343–7350, 2014.

43)  El-Baba, T.J.,# Lutomski, C.A.,# Wang, B., Trimpin, S., Characterizing Synthetic Polymers and Additives using New Ionization Methods for Mass Spectrometry. Rapid Commun. Mass Spectrom. 28(11): 1175–1184, 2014. #contributed equally

42)  Wang, B., Trimpin, S., High Throughput Solvent Assisted Ionization Inlet (SAII) for Use in Mass Spectrometry. Anal. Chem. 86(2): 1000–1006, 2014.

41)  Pagnotti, V.S, Chakrabarty, S., Wang, B., Trimpin, S., McEwen, C.N., Gas-Phase Ions Produced by Freezing Water or Methanol for Analysis Using Mass Spectrometry. Anal. Chem. 86(15): 7343–7350, 2014.

40)  Wang, B., Akhmetova, E., Trimpin, S., Wilkins, C.L., Matrix-Assisted Ionization Vacuum for High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometers. Anal. Chem. 86(14): 6792–6796, 2014. (Technical Note)

39)  Lutomski, C.A.,# El-Baba, T.J.,# Inutan E.D., Manly, C.D., Trimpin, S., Transmission Geometry Laserspray Ionization Vacuum Using an Atmospheric Pressure Inlet. Anal. Chem. 86(13): 6208–6213, 2014.  (Technical Note) #contributed equally

38)  Chakrabarty, S., Pagnotti, V.S., Inutan, E.D., Trimpin, S., McEwen, C.N., A New Matrix Assisted Ionization Method for the Analysis of Volatile and Nonvolatile Compounds by Atmospheric Probe Mass Spectrometry. J. Am. Soc. Mass Spectrom. 24(7): 1102–1107, 2013.

  • This paper was highlighted on the cover page of the journal.

37)  Inutan, E.D., Wager-Miller, J., Narayan, S.B., Mackie, K., Trimpin, S., The Potential for Clinical Applications using a New Ionization Method Combined with Ion Mobility Spectrometry-Mass Spectrometry. Int. J. Ion Mobility Spectrom. 16(2): 145–159, 2013. Invited contribution for a special issue entitled ‘Travelling Wave IMS’

36)  Trimpin, S., Inutan, E.D., New Ionization Method for Rapid Analysis on Atmospheric Pressure Ionization Mass Spectrometers Requiring Only Vacuum and Matrix Assistance. Anal. Chem. 85(4): 2005–2009, 2013. (Letters to Analytical Chemistry)

35)  Pagnotti, V.S., Chakrabarty, S., McEwen, C.N., Carbonation and Other Super Saturated Gases as Solution Modifiers for Improved Sensitivity in Solvent Assisted Ionization Inlet (SAII) and ESI. J. Am. Soc. Mass Spectrom. 24: 186–192, 2013.

34)  Trimpin, S., Inutan, E.D., Matrix Assisted Ionization in Vacuum, A Sensitive and Widely Applicable Ionization Method for Mass Spectrometry. J. Am. Soc. Mass Spectrom. 24(5): 722–732, 2013.

33)  Inutan, E.D., Trimpin, S., Matrix Assisted Ionization Vacuum, a New Ionization Method for Biological Materials Analysis using Mass Spectrometry. Mol. Cell. Proteomics 12(3): 792–796, 2013.

31)  Nyadong, L., Inutan, E.D., Wang, X., Hendrickson, C.L., Trimpin, S., Marshall, A.G., Laserspray and Matrix Assisted Inlet Ionization Coupled to High-Field Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Peptide and Protein Analysis. J. Am. Soc. Mass Spectrom. 24(3): 320–328, 2013.

30)  Chubatyi, N.D., Pagnotti, V.S., Bentzley, C.M., McEwen, C.N., High Sensitivity Steroid Analysis using Liquid Chromatography/Solvent-assisted Inlet Ionization Mass Spectrometry. Rapid Commun. Mass Spectrom. 26: 887–892, 2012.

29)  Zydel, F., Smith, J.R., Pagnotti, V.S., Lawrence, R.J., McEwen, C.N., Capacio, B.R., Rapid Screening of Chemical Warfare Nerve Agent Metabolites in Urine by Atmospheric Solids Analysis Probe-Mass Spectroscopy (ASAP-MS). Drug Testing and Analysis 4(3-4): 308–311, 2012.

28)  Trimpin, S., Wang, B., Inutan, E.D., Li, J., Lietz, C.B., Pagnotti, V.S., Harron, A.F., Sardelis, D., McEwen, C.N., A Mechanism for Ionization of Nonvolatile Compounds in Mass Spectrometry: Considerations from MALDI and Inlet Ionization. J. Am. Soc. Mass Spectrom. 23(10): 1644–1660, 2012. Downloaded 305 times (top 5 as of Oct. 24, 2012) in 90 days after paper published in October 2012 issue.  Highlighted on the JASMS homepage June 29, 2015.

27)  Li, J., Inutan, E.D., Wang, B., Lietz, C.B., Green, D.R., Manly, C.D., Richards, A.L., Marshall, D.D., Lingenfelter, S., Ren, Y., Trimpin, S., Matrix Assisted Ionization: New Aromatic and Non Aromatic Matrix Compounds Producing Multiply Charged Lipid, Peptide, and Protein Ions in the Positive and Negative Mode Observed Directly from Surfaces. J. Am. Soc. Mass Spectrom. 23(10): 1625–1643, 2012. Downloaded 297 times (top 5 as of Nov. 3, 2012) in 90 days after paper published in October 2012 issue

26)  Pagnotti, V.S., Chakrabarty, S., Harron, A.F., McEwen, C.N., Increasing the Sensitivity of Liquid Introduction Mass Spectrometry by Combining Electrospray Ionization and Solvent Assisted Inlet Ionization. Anal. Chem. 84: 6828–6832, 2012.

25)  Wang, B., Inutan, E.D., Trimpin, S., A New Approach to High Sensitivity Liquid Chromatography-Mass Spectrometry of Peptides using Nanoflow Solvent Assisted Inlet Ionization. J. Am. Soc. Mass Spectrom. 23(3): 442–445, 2012.

24)  Chubatyi, N.D., Wang, T., McEwen, C.N., More Inclusive or Selective Ionization for Mass Spectrometry using Obstructive Sonic Spray Ionization and Voltage Polarity Switching. Rapid Commun. Mass Spectrom. 26: 2763–2769, 2012.

23)  Inutan, E.D., Wager-Miller, J., Mackie, K., Trimpin, S., Laserspray Ionization Imaging of Multiply Charged Ions using a Commercial Vacuum MALDI Ion Source. Anal. Chem. 84(21): 9079–9084, 2012.

22)  Richards, A.L., Lietz, C.B., Wager-Miller, J., Mackie, K., Trimpin, S., Localization and Imaging of Gangliosides in Mouse Brain Tissue Sections by Laserspray Ionization Inlet. J. Lipid Res. 53(7): 1390–1398, 2012.

21)  Pagnotti, V.S., Inutan, E.D., Marshall, D.D., McEwen, C.N., Trimpin, S., Inlet Ionization:  A New Highly Sensitive Approach for Liquid Chromatography-Mass Spectrometry of Small and Large Molecules. Anal. Chem. 83(20): 7591–7594, 2011.

20)  Trimpin, S., Ren, Y., Wang, B., Lietz, C.B., Richards, A.L., Marshall, D.D., Inutan, E.D., Extending the Laserspray Ionization Concept to Produce Highly Charged Ions at High Vacuum on a Time-of-Flight Mass Analyzer. Anal. Chem. 83(14): 5469–5475, 2011. (Letters to Analytical Chemistry)

19)  Wang, B., Lietz, C.B., Inutan, E.D., Leach, S.M., Trimpin, S., Producing Highly Charged Ions without Solvent using Laserspray Ionization: A Total Solvent-free Analysis Approach at Atmospheric Pressure. Anal. Chem. 83(11): 4076–4084, 2011.

18)  Richards, A.L., Lietz, C.B., Wager-Miller, J., Mackie, K., Trimpin, S., Imaging Mass Spectrometry in Transmission Geometry. Rapid Commun. Mass Spectrom. 25(6): 815–820, 2011. (Letter to the Editor)

17)  McEwen, C.N., Trimpin, S., An Alternative Ionization Paradigm for Atmospheric Pressure Mass Spectrometry: Flying Elephants from Trojan Horses. Int. J. Mass Spectrom. 300(2-3): 167–172, 2011.  (Invited contribution for special issue honoring Prof. John B. Fenn.)

16)  Inutan, E.D., Richards, A.L., Wager-Miller, J., Mackie, K., McEwen, C.N., Trimpin, S., Laserspray Ionization – A New Method for Protein Analysis Directly from Tissue at Atmospheric Pressure with Ultrahigh Mass Resolution and Electron Transfer Dissociation. Mol. Cell. Proteomics 10(2): 1–8, 2011.

15)  Richards, A.L., Marshall, D.D., Inutan, E.D., McEwen, C.N., Trimpin, S., High Throughput Analysis of Peptides and Proteins by Laserspray Ionization Mass Spectrometry. Rapid Commun. Mass Spectrom. 25(1): 247–250, 2011. (Letter to the Editor)

34)  Lietz, C.B., Richards, A.L., Ren, Y., Trimpin, S., Inlet Ionization: Protein Analyses from the Solid State Without the Use of a Voltage or a Laser Producing up to 67 Charges on the 66 kDa BSA Protein. Rapid Commun. Mass Spectrom. 25(22): 3453–3456, 2011.

14)  Pagnotti, V.S., Inutan, E.D., Marshall, D.D., McEwen, C.N., Trimpin, S., Inlet Ionization: A New Highly Sensitive Approach for Liquid Chromatography-Mass Spectrometry of Small and Large Molecules. Anal. Chem. 83(20): 7591–7594, 2011.

13)  Pagnotti, V.S., Chubatyi, N.D., McEwen, C.N., Solvent Assisted Inlet Ionization: an Ultrasensitive New Liquid Introduction Ionization Method for Mass Spectrometry. Anal. Chem. 83:3981–3985, 2011.

12)  McEwen, C.N., Pagnotti, V., Inutan, E.D., Trimpin, S., New Paradigm in Ionization: Multiply Charged Ion Formation from a Solid Matrix without a Laser or Voltage. Anal. Chem. 82(22): 9164–9168, 2010. (Letters to Analytical Chemistry)

11)  Inutan, E.D., Wang, B., Trimpin, S., Commercial Intermediate Pressure MALDI Ion Mobility Spectrometry Mass Spectrometer Capable of Producing Highly Charged Laserspray Ionization Ions. Anal. Chem. 83(3): 678–684, 2010. (Letters to Analytical Chemistry)

10)  Inutan, E.D., Trimpin, S., Laserspray Ionization-Ion Mobility Spectrometry-Mass Spectrometry: Baseline Separation of Isomeric Amyloids without the Use of Solvents Desorbed and Ionized Directly from a Surface. J. Proteome Res. 9(11): 6077–6081, 2010.

9)  Zydel, F., Trimpin, S., McEwen, C.N., Laserspray Ionization Using an Atmospheric Solids Analysis Probe for Sample Introduction. J. Am. Soc. Mass Spectrom. 21(11): 1889–1892, 2010. (Application note)

8)  McEwen, C.N., Larsen, B.S., Trimpin, S., Laserspray Ionization on a Commercial Atmospheric Pressure-MALDI Mass Spectrometer Ion Source: Selecting Singly or Multiply Charged Ions. Anal. Chem. 82(12): 4998–5001, 2010. (Letters to Analytical Chemistry)

7)  Inutan, E.D., Trimpin, S., Laserspray Ionization (LSI) Ion Mobility Spectrometry (IMS) Mass Spectrometry. J. Am. Soc. Mass Spectrom. 21(7): 1260–1264, 2010. (Short Communication)

6)  Trimpin, S., Inutan, E.D., Herath, T.N., McEwen, C.N., Laserspray Ionization – A New Atmospheric Pressure MALDI Method for Producing Highly Charged Gas-Phase Ions of Peptides and Proteins Directly from Solid Solutions. Mol. Cell. Proteomics 9(2): 362–367, 2010.

5)  Trimpin, S., Inutan, E.D., Herath, T.N., McEwen, C.N., Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Method for Selectively Producing Either Singly or Multiply Charged Molecular Ions. Anal. Chem. 82(1): 11–15, 2010. (Letters to Analytical Chemistry)

4)  Trimpin, S., Wijerathne, K., McEwen, C.N., Rapid Methods of Polymer and Polymer Additives Identification: Multi-sample Solvent-free MALDI, Pyrolysis at Atmospheric Pressure, and Atmospheric Solids Analysis Probe Mass Spectrometry. Anal. Chim. Acta 654(1): 20–25, 2009.

3)  Lloyd, J.A., Harron, A.F., McEwen, C.N., Combination Atmospheric Pressure Solids Analysis Probe and Desorption Electrospray Ionization Mass Spectrometry Ion Source. Anal. Chem. 81(21): 9158–9162, 2009.

2)  McEwen, C.N., Larsen, B.S., Ionization Mechanisms Related to Negative Ion APPI, APCI, and DART. J. Am. Soc. Mass Spectrom. 20(8): 1518–1521, 2009.

1)  McEwen, C.N., McKay, R.G., Larsen, B.S., Analysis of Solids, Liquids, and Biological Tissues using Solid Probe Introduction at Atmospheric Pressure on Commercial LC/MS Instruments. Anal. Chem. 77: 7826–7831, 2005.

III. Conventional Ionization Methods of ESI and MALDI

A) Peer-reviewed papers

A. Book and Book Chapters

2)  Trimpin, S., Clemmer, D.E., Larsen, B.S. Snapshots, Conformation, and Bulk Fragmentation Analyses for the Characterization of Polymeric Architectures using ESI-IMS-MS, in: Ion Mobility Spectrometry: Theory and Applications, Taylor and Francis Group, by Eds. Charles L. Wilkins and Sarah Trimpin, pp. 215-236, 2010.

1)  Trimpin, S. Solvent-free MALDI Sample Preparation, in: MALDI Mass Spectrometry for Synthetic Polymer Analysis, Wiley-Interscience by Editor Lang Li, pp. 159-186, 2009.

B. Invited Review and Other Articles

4)  Weidner, S.M., Trimpin, S., Mass Spectrometry of Synthetic Polymers. Anal. Chem. 82(12): 4811–4829, 2010. (Review)

3)  Trimpin, S., Brizzard, B.L., Analysis of Insoluble Proteins. BioTechn. 46(6):409–419, 2009. (Mini-Review)

2)  Weidner, S.M., Trimpin, S., Mass Spectrometry of Synthetic Polymers. Anal. Chem. 80(12):4349–4361, 2008. (Review)

1)  Trimpin, S., Deinzer, M.L., Solvent-free Mass Spectrometry for Hydrophobic Peptide Sequence Analysis and Protein Conformation Studies. BioTechn. 39(6):799–805, 2005.

C. Peer-Reviewed Research Publications

23) Cao, Y., Lee, C., Davis, E.T.J., Si, W., Wang, F., Trimpin, S., Luo, L., 1000-Fold Preconcentration of Per- and Polyfluorinated Alkyl Substances (PFAS) within 10 min via Electrochemical Aerosol Formation. Anal. Chem. 91(22): 14352-14358, 2019.

  • This paper was highlighted on the cover page of the journal.

22) Foley, C.D., Zhang, B., Alb, A.M., Trimpin, S., Grayson, S.M., Use of Ion Mobility Spectrometry-Mass Spectrometry to Elucidate Arm-Dispersity within Star Polymers, ACS Macro Letters 4(7): 778–782, 2015.

21) Hoskins, J.N., Trimpin, S., Grayson, S.M., Architectural Differentiation of Linear and Cyclic Polymeric Isomers by Ion Mobility Spectrometry-Mass Spectrometry. Macromolecules 44(17): 6915–6918, 2011.

20) Trimpin, S., Herath, T.N., Inutan, E.D., Wager-Miller, J., Kowalski, P., Claude, E., Walker, J.M., Mackie, K. Automated Solvent-free Matrix Deposition for Tissue Imaging by Mass Spectrometry. Anal. Chem. 82(1): 359–367, 2010.

19) Trimpin, S., Herath, T.N., Inutan, E.D., Cernat, S.A., Wager-Miller, J., Mackie, K., Walker, J.M., Field-free transmission geometry atmospheric pressure matrix-assisted laser desorption/ionization for rapid analysis of unadulterated tissue samples. Rapid Commun. Mass Spectrom. 23(18): 3023–3027, 2009. (Letter to the Editor)

18) Trimpin, S., Tan, B., O’Dell, D.K., Bohrer, B.C., Merenbloom, S.I., Pazos, M.X., Clemmer, D.E., Walker, J.M., Profiling of Phospholipids and Related Lipid Structures using Multidimensional Ion Mobility Spectrometry-Mass Spectrometry. Int. J. Mass Spectrom. 287(1-3): 58–69, 2009.  (Invited contribution, special issue honoring Prof. Charles L. Wilkins)

17) Trimpin, S., Clemmer, D.E., Ion Mobility Spectrometry/Mass Spectrometry Snapshots for Assessing the Molecular Compositions of Complex Polymeric Systems. Anal. Chem. 80(23): 9073–9083, 2008.

16) Trimpin, S., Plasencia, M.D., Isailovic, D., Clemmer, D.E., Resolving Oligomers from Fully Grown Polymers with IMS-MS. Anal. Chem. 79(21): 7965–7974, 2007. (accelerated article)

15) Trimpin, S., Clemmer, D.E., McEwen, C.N., Charge-remote fragmentation of lithiated fatty acids on a TOF-TOF instrument using matrix-ionization. J. Am. Soc. Mass Spectrom. 18(1): 1967–1972, 2007. (accelerated Short Communication)

14) Trimpin, S., Weidner, S.M., Falkenhagen, J., McEwen, C.N., Fractionation and Solvent-free MALDI-MS Analysis of Polymers using Liquid Adsorption Chromatography at Critical Conditions in Combination with a Multisample On-Target Homogenization/Transfer Sample Preparation Method. Anal. Chem. 79(19): 7565–7570, 2007.

13) Trimpin, S., Deinzer, M.L., Solvent-free MALDI-MS for the Analysis of β-Amyloid Peptides via the Mini-Ball Mill Approach: Qualitative and Quantitative Advances. J. Am. Soc. Mass Spectrom. 18(8): 1533–1543, 2007.

12) Liu, X., Valentine, S.J., Plasencia, M.D., Trimpin, S., Naylor, S., Clemmer, D.E., Mapping the Human Plasma Proteome by SCX-LC-IMS-MS. J. Am. Soc. Mass Spectrom. 18(7): 1249–1264, 2007.

11) Trimpin, S., McEwen, C.N., Multisample Preparation Methods for the Solvent-free MALDI-MS Analysis of Synthetic Polymers. J. Am. Soc. Mass Spectrom. 18(3): 377–381, 2007.

10) Trimpin, S., Deinzer, M.L., Solvent-free MALDI-MS for the Analysis of a Membrane Protein via the Mini Ball Mill Approach: Case Study of Bacteriorhodopsin. Anal. Chem. 79(1): 71–78, 2007.

9)  Trimpin, S., Keune, S., Räder, H.J., Müllen, K., Solvent-free MALDI-MS: Developmental Improvements in the Reliability and the Potential of MALDI Analysis of Synthetic Polymers and Giant Organic Molecules. J. Am. Soc. Mass Spectrom. 17(5): 661–671, 2006.

8)  Trimpin, S., Räder, H.J., Müllen, K., Investigations of Theoretical Principles for MALDI-MS derived from solvent-free sample preparation – Part I. Preorganization. Int. J. Mass Spectrom. 253(1-2): 13–21, 2006.

7)  Trimpin, S., Deinzer, M.L., Solvent-free MALDI-MS for the Analysis of Biological Samples via a Mini-Ball Mill Approach. J. Am. Soc. Mass Spectrom. 16(4): 542–547, 2005.

6)  Trimpin, S., Mixon, A.E., Stapels, M., Kim, M.-Y., Spencer, P.S., Deinzer, M.L., Identification of Endogenous Phosphorylation Sites of Bovine Medium and Low Molecular Weight Neurofilament Proteins by Tandem Mass Spectrometry. Biochem. 43(7): 2091–2105, 2004.

5)  Laine, O., Trimpin, S., Räder, H.J., Müllen, K., Changes in Post-Source Decay Fragmentation Behavior of Poly(methylmethacrylate) Polymers with Increasing Molecular Weight Studied by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. Eur. J. Mass Spectrom. 9(3): 195–201, 2003.

4)  Trimpin, S., Grimsdale, A.C., Räder, H.J., Müllen, K., Characterization of an Insoluble Poly(9,9-diphenyl-2,7-fluorene) by Solvent-Free Sample Preparation for MALDI-TOF Mass Spectrometry. Anal. Chem. 74(15): 3777–3782, 2002.

3)  Trimpin, S., Eichhorn, P., Räder, H.J., Müllen, K., Knepper, T.P., Recalcitrance of Poly(vinylpyrrolidone): Evidence through Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. J. Chrom. A 938(1-2): 67–77, 2001.

2)  Trimpin, S., Rouhanipour, A., Az, R., Räder, H.J., Müllen, K., New Aspects in Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry: a Universal Solvent-Free Sample Preparation. Rapid Commun. Mass Spectrom. 15(15): 1364–1373, 2001.

1)  Leuninger, J., Trimpin, S., Räder, H.J., Müllen, K., Novel Approach to Ladder-Type Polymers: Polydithiathianthrene via the Intramolecular Acid-Induced Cyclization of Methylsulfinyl-Substituted Poly(meta-phenylene sulfide). Macromol. Chem. Phys. 202(14): 2832–2842, 2001.

  • This paper was highlighted on the cover page of the journal.