Note: Work related to MSTM Products (highlighted in blue color)

 

A) SPECIAL JOURNAL ISSUE ON ‘NOVEL IONIZATION PROCESSES IN MASS SPECTROMETRY (Rapid Communications in Mass Spectrometry, Guest Editor Trimpin) (Coming Soon!)

 

1)      Apsokardu, M.J., Kerecman, D.E., Johnston, M.V., Ion Formation in Droplet Assisted Ionization. Rapid Commun. Mass Spectrom. 2019. DOI: 10.1002/rcm.8227.

2)      Hale, O., Ryumin, P., Brown, J., Morris, M., Cramer, R., Production and Analysis of Multiply Charged Negative Ions by Liquid AP-MALDI MS. Rapid Commun Mass Spectrom. 2019. DOI: 10.1002/rcm.8246

3)      Li, X., Attanayake, K., Valentine, S.J., Li, P., Vibrating sharp-edge spray ionization (VSSI) for voltage-free direct analysis of samples using mass spectrometry. Rapid Commun. Mass Spectrom. 2019. DOI:10.1002/rcm.8232.

4)      Liyanage, R., Gidden, J., Wilkins, C.L., Lay, J.O. (Jr), MAI-FTMS for the Analysis of Lipids. Rapid Commun. Mass Spectrom. 2019. DOI: 10.1002/rcm.8349.

5)      Lee, C., Inutan, E.D., Chen, J.L., Mukeku, M.M., Weidner. S.M., Trimpin, S., Ni, C.K., Toward Understanding of the Ionization Mechanism of Matrix-Assisted Ionization using Mass Spectrometry Experiment and Theory. Rapid Commun. Mass Spectrom. 2019. (accepted to Special Issue on New Ionization Processes)

6)      Karki, S., Meher, A.K., Inutan, E.D., Pophristic, M., Marshall, D.D., Rackers, K., Trimpin, S., McEwen, C.N., Development of a Robotics Platform for Automated Multi-ionization Mass Spectrometry. Rapid Commun. Mass Spectrom. 2019. (accepted to Special Issue on New Ionization Processes)

7)      There are more contributions but can’t be included to this list at this time.

 

B. PUBLICATIONS: Related Fundamental Research by Professors Trimpin and McEwen

 

I.  Book Chapters

1)      Trimpin, S., Wang, B., Inlet and Vacuum Ionization from Ambient Conditions, Ambient Ionization Mass Spectrometry. Book Series: New Developments in NMR. Issue: 2, pp. 423–444, 2015.

2)      McEwen, C.N., Lieu, T., Saylor, S., Twohig, M., Balogh, M.P., Atmospheric Samples Analysis Probe (ASAP) Mass Spectrometry. Ambient Ionization Mass Spectrometry. Book Series: New Developments in NMR. Issue: 2, pp. 104–119, 2015.

3)      Lietz, C.B., Richards, A.L., Marshall, D.D., Ren. Y., Trimpin, S., Matrix Assisted Inlet Ionization and Solvent-free Gas-Phase Separation using Ion Mobility Spectrometry for Imaging and Electron Transfer Dissociation Mass Spectrometry of Polymers, in: Mass Spectrometry in Polymer Chemistry, Wiley-VCH, by Eds. Christopher Barner-Kowollik, Till Gründling, Jana Falkenhagen, and Steffen Weidner, pp. 85118, 2012.

4)      McEwen, C.N., Major, H., Green, M., Giles, K., Trimpin, S. IMS/MS Applied to Direct Ionization using the Atmospheric Solids Analysis Probe Method Ion Mobility Spectrometry, in: Ion Mobility Spectrometry: Theory and Applications, Taylor and Francis Group, by Eds. Charles L. Wilkins and Sarah Trimpin, pp. 171–188, 2010.

 

II. Invited Review and Other Articles

 

1)      Trimpin, S., Novel Ionization Processes for Use in Mass Spectrometry: ‘Squeezing’ Nonvolatile Analyte Ions from Crystals and Droplets.  A Perspective of Ionization in Mass Spectrometry. Rapid Commun. Mass Spectrom. DOI: 10.1002/rcm.8269.

This paper was selected to be highlighted on the cover page of the journal

2)      Trimpin, S., Karki, S., Marshall, D.D., Inutan, E.D., Meher, A.K., Madarshahian, S., Fenner, M.A., McEwen, C.N., Novel and Traditional Ionization Methods for Mass Spectrometry Combined to Provide More Comprehensive Analyses. LCGC North America, 2018, March issue, 35(8), 507–510. 

3)      Trimpin, S., Redefining Simplicity in Ionization: Discovery and Implementation of Novel Ionization Processes in Mass Spectrometry. LCGC North America, 2017, August issue, Vol. 35, Issue 8, pp. 507–510. 

4)      Peacock, P.M., Zhang, W.J., Trimpin, S., Advances in Ionization for Mass Spectrometry, Anal. Chem. 89(1): 372−388, 2017. (invited contribution to the 2017 Special)

5)      Trimpin, S.,     Analytical Scientist highlighted In My View (an invited opinion article on MS Technology), 2016, September issue, pages 18–19.

6)      Trimpin, S., Thawoos, S., Lu, I-C., DeLeeuw, J.L., Hoang, K., Devereaux, Z.J., Pophristic, M., Chakrabarty, S., Caruso, J.A., Stemmer, P.M., Narayan, S.B., McEwen, C.N., Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drug and Clinical Analyses. LCGC and Spectroscopy, 2016, May issue, pages 8–19.

7)      Trimpin, S., Wang, B., Lutomski, C.A., El-Baba, T.J., Harless, B.M., A Convenient Alternative to MALDI and ESI, by request of the journal republished in ‘Current Trends in Mass Spectrometry’ (www. spectroscopyonline.com), LCGC and Spectroscopy, 2016, March issue, pages 53–61.

8)      Hassan, L., McEwen, C.N., Solvent Assisted Ionization Mass Spectrometry for Screening and Quantification of Counterfeit Drugs. Spectroscopy. Special Issue, 2015, Volume 13, Issue 3, pp. 8–13.

9)      Trimpin, S., “Magic” Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. 27(1): 4–21, 2016. (invited Critical Insight Article dedicated for controversial topics and established experts in the field) 

10)  McEwen, C.N., Larsen, B.S., Fifty years of desorption ionization of nonvolatile compounds. Int. J. Mass Spectrom. 377:515–531, 2015.

11)  Trimpin, S., Chakrabarty, S., Wang, B., Hoang, K., Lutomski, C.A., Inutan, E.D., McEwen, C.N., Non-Conventional Alternatives to LC/MS, LCGC and Spectroscopy, 2015, May issue, pages 22–33.

12)  Trimpin, S., Wang, B., Lutomski, C.A., El-Baba, T.J, Harless, B.M., A Convenient Alternative to MALDI and ESI, in ‘Current Trends in Mass Spectrometry’ (www. spectroscopyonline.com), LCGC and Spectroscopy, 2014, May issue, pages 8–17.

13)  El-Baba, T.J, Lutomski, C.A., Wang, B., Inutan, E.D., Trimpin, S., Toward High Spatial Resolution Sampling and Characterization of Biological Tissue Surfaces using Mass Spectrometry. Anal. Bioanal. Chem. 406(17):4053–4061, 2014. (Review)

14)  Trimpin, S., Wang, B., Lietz, C.B., Marshall, D.D., Richards, A.L., Inutan, E.D., New Ionization Processes and Applications for Use in Mass Spectrometry. Crit. Rev. Biochem. Mol. Biol. 48(5):409–429, 2013. (Review)

 

III. Peer-Reviewed Research Publications

1)      Trimpin, S., Pophristic, M., Adeniji’Adele, A., Tomsho, J.W., McEwen, C.N., Vacuum Matrix-Assisted Ionization Source Offering Simplicity, Sensitivity, and Exceptional Robustness in Mass Spectrometry. Anal. Chem. 90(19): 11188-11192, 2018.

2)      Trimpin, S., Lu, I-C., Rauschenbach, S., Hoang, K., Wang, B., Chubatyi, N.D., Zhang, W.-J., Inutan, E.D., Pophristic, M., Sidorenko, A., McEwen, C.N., Spontaneous Charge Separation and Sublimation Processes are Ubiquitous in Nature and in Ionization Processes in Mass Spectrometry. J. Am. Soc. Mass Spectrom. 29(2): 304–315, 2018. (Invited contribution to special issue on Asilomar Conference) 

3)      Madarshahian, S., Pophristic, M., McEwen, C.N., Infrared atmospheric solids analysis probe (IRASAP) mass spectrometry for ambient analysis of volatile compounds without heated gas. Anal. Methods 9(34): 5009-5014, 2017. (Invited contribution to special issue on ambient ionization)

4)      Lu, I-C., Elia, E.A., Zhang, W.-J., Pophristic, M., Inutan, E.D., McEwen, C.N., Trimpin, S., Development of an Easily Adaptable, High Sensitivity Source for Inlet Ionization. Anal. Methods 9(34): 4971–4978, 2017. (Invited contribution to special issue on ambient ionization) 

5)      Fenner, M.A., Chakrabarty, S., Wang, B., Pagnotti, V.S., Hoang, K., Trimpin, S., McEwen, C.N., A New LC/MS Method Providing Improved Sensitivity: Electrospray Ionization Inlet. Anal. Chem. 89(9): 4798–4802, 2017. 

6)      Lu, I.C., Pophristic, M., Inutan, E.D., McKay, R.G., McEwen, C.N., Trimpin, S., Simplifying the ion source for mass spectrometry. Rapid Commun. Mass Spectrom. 30: 2568–2572, 2016.

7)      Hoang, K., Pophristic, M., Horan, A.J., Johnston, M.V., McEwen, C.N., High Sensitivity Analysis of Nanoliter Volumes of Volatile and Nonvolatile Compounds using Matrix Assisted Ionization (MAI) Mass Spectrometry. J. Am. Soc. Mass Spectrom. 27: 1591–1596, 2016.

8)      Devereaux, Z.J., Reynolds, C.A., Fischer, J.L., Foley, C.D., DeLeeuw, J.L., Wager-Miller, J., Narayan, S.B., Mackie, K., Trimpin, S., Matrix-Assisted Ionization (MAI) on a Portable Mass Spectrometer: Analysis Directly from Biological and Synthetic Materials. Anal. Chem. 88(22): 10831–10836, 2016. 

9)      Marshall, D.D., Inutan, E.D., Wang, B., Liu, C.W., Thawoos, S., Wager-Miller, J., Mackie, K., Trimpin, S., A Broad-based Study on Hyphenating New Ionization Technologies with MS/MS for PTM’s and Tissue Characterization. Proteomics 16(11-12): 1695–1706, 2016. (Invited paper) 

10)  Trimpin, S., Thawoos, S., Foley, C.D., Woodall, D.W., Li, J., Inutan, E.D., Stemmer, P.M., Rapid High Mass Resolution Mass Spectrometry using Matrix-Assisted Ionization. Methods 104: 63–68, 2016. (Invited paper) 

11)  Fischer, J.L., Lutomski, C.A., El-Baba, T.J., Siriwardena-Mahanama, B.N., Weidner, S.M., Falkenhagen, J., Allen, M.J., Trimpin, S., Matrix-Assisted Ionization-Ion Mobility Spectrometry-Mass Spectrometry: Selective Analysis of a Europium-PEG Complex in a Crude Mixture. J. Am. Soc. Mass Spectrom. 26(12): 2086–2095, 2015. 

12)  Chakrabarty, S., DeLeeuw, J.L., Woodall, D.W., Jooss, K., Narayan, S.B., Trimpin, S., Reproducibility and Quantitation of Illicit Drugs using Matrix-Assisted Ionization (MAI) Mass Spectrometry. Anal. Chem. 87(16): 8301–8306, 2015.  

13)  Wang, B., Dearring, C.L., Wager-Miller, J., Mackie, K., Trimpin, S., Drug Detection and Quantification Directly from Tissue using Novel Ionization Methods for Mass Spectrometry. Eur. J. Mass Spectrom. 21(3): 201–210, 2015. (Invited contribution to special 20th Anniversary Issue)

14)  Fenner, M.A., McEwen, C.N., Survival Yield Comparison between ESI and SAII: Mechanistic Implications. Int. J. Mass Spectrom. 378: 107–112, 2015.

15)  Woodall, D.W., Wang, B., Inutan, E.D., Narayan, S.B., Trimpin, S., High-throughput Characterization of Small and Large Molecules Using Only a Matrix and the Vacuum of a Mass Spectrometer. Anal. Chem. 87(9): 4667–4674, 2015.  

16)  Chubatyi, N.D., McEwen, C.N., Improving the Sensitivity of Matrix-Assisted Ionization (MAI) Mass Spectrometry Using Ammonium Salts. J. Am. Soc. Mass Spectrom. 26: 1649–1656, 2015.

17)  Trimpin, S., Lutomski, C.A., El-Baba, T.J., Woodall, D.W., Foley, C.D., Manly, C.D., Wang, B., Liu, C.W., Harless, B.M., Kumar, R., Imperial, L.F., Inutan, E.D., Magic Matrices for Ionization in Mass Spectrometry. Int. J. Mass Spectrom. 377(SI): 532–545, 2015. Invited contribution to 100th year of Mass Spectrometry special issue. 

18)  Pagnotti, V.S, Chakrabarty, S., Wang, B., Trimpin, S., McEwen, C.N., Gas-Phase Ions Produced by Freezing Water or Methanol for Analysis Using Mass Spectrometry. Anal. Chem. 86(15): 7343–7350, 2014. 

19)  El-Baba, T.J.,# Lutomski, C.A.,# Wang, B., Trimpin, S., Characterizing Synthetic Polymers and Additives using New Ionization Methods for Mass Spectrometry. Rapid Commun. Mass Spectrom. 28(11): 1175–1184, 2014. #contributed equally 

20)  Wang, B., Trimpin, S., High Throughput Solvent Assisted Ionization Inlet (SAII) for Use in Mass Spectrometry. Anal. Chem. 86(2): 1000–1006, 2014.   

21)  Chakrabarty, S., Pagnotti, V.S., Inutan, E.D., Trimpin, S., McEwen, C.N., A New Matrix Assisted Ionization Method for the Analysis of Volatile and Nonvolatile Compounds by Atmospheric Probe Mass Spectrometry. J. Am. Soc. Mass Spectrom. 24(7): 1102–1107, 2013.   

This paper was selected to be highlighted on the cover page of the journal (July issue 2013)

22)  Inutan, E.D., Wager-Miller, J., Narayan, S.B., Mackie, K., Trimpin, S., The Potential for Clinical Applications using a New Ionization Method Combined with Ion Mobility Spectrometry-Mass Spectrometry. Int. J. Ion Mobility Spectrom. 16(2): 145–159, 2013. Invited contribution for a special issue entitled ‘Travelling Wave IMS’ 

23)  Trimpin, S., Inutan, E.D., New Ionization Method for Rapid Analysis on Atmospheric Pressure Ionization Mass Spectrometers Requiring Only Vacuum and Matrix Assistance. Anal. Chem. 85(4): 2005–2009, 2013. (Letters to Analytical Chemistry)   

24)  Pagnotti, V.S., Chakrabarty, S., McEwen, C.N., Carbonation and Other Super Saturated Gases as Solution Modifiers for Improved Sensitivity in Solvent Assisted Ionization Inlet (SAII) and ESI. J. Am. Soc. Mass Spectrom. 24: 186–192, 2013.

25)  Trimpin, S., Inutan, E.D., Matrix Assisted Ionization in Vacuum, A Sensitive and Widely Applicable Ionization Method for Mass Spectrometry. J. Am. Soc. Mass Spectrom. 24(5): 722–732, 2013. 

26)  Inutan, E.D., Trimpin, S., Matrix Assisted Ionization Vacuum, a New Ionization Method for Biological Materials Analysis using Mass Spectrometry. Mol. Cell. Proteomics 12(3): 792–796, 2013. 

27)  Chubatyi, N.D., Pagnotti, V.S., Bentzley, C.M., McEwen, C.N., High Sensitivity Steroid Analysis using Liquid Chromatography/Solvent-assisted Inlet Ionization Mass Spectrometry. Rapid Commun. Mass Spectrom. 26: 887–892, 2012.

28)  Zydel, F., Smith, J.R., Pagnotti, V.S., Lawrence, R.J., McEwen, C.N., Capacio, B.R., Rapid Screening of Chemical Warfare Nerve Agent Metabolites in Urine by Atmospheric Solids Analysis Probe-Mass Spectroscopy (ASAP-MS). Drug Testing and Analysis 4(3-4): 308–311, 2012.

29)  Trimpin, S., Wang, B., Inutan, E.D., Li, J., Lietz, C.B., Pagnotti, V.S., Harron, A.F., Sardelis, D., McEwen, C.N., A Mechanism for Ionization of Nonvolatile Compounds in Mass Spectrometry: Considerations from MALDI and Inlet Ionization. J. Am. Soc. Mass Spectrom. 23(10): 1644–1660, 2012.  Downloaded 305 times (top 5 as of Oct. 24, 2012) in 90 days after paper published in October 2012 issue.  Highlighted on the JASMS homepage June 29, 2015.

30)  Li, J., Inutan, E.D., Wang, B., Lietz, C.B., Green, D.R., Manly, C.D., Richards, A.L., Marshall, D.D., Lingenfelter, S., Ren, Y., Trimpin, S., Matrix Assisted Ionization: New Aromatic and Non Aromatic Matrix Compounds Producing Multiply Charged Lipid, Peptide, and Protein Ions in the Positive and Negative Mode Observed Directly from Surfaces. J. Am. Soc. Mass Spectrom. 23(10): 1625–1643, 2012.  Downloaded 297 times (top 5 as of Nov. 3, 2012) in 90 days after paper published in October 2012 issue

31)  Pagnotti, V.S., Chakrabarty, S., Harron, A.F., McEwen, C.N., Increasing the Sensitivity of Liquid Introduction Mass Spectrometry by Combining Electrospray Ionization and Solvent Assisted Inlet Ionization. Anal. Chem. 84: 6828–6832, 2012.

32)  Wang, B., Inutan, E.D., Trimpin, S., A New Approach to High Sensitivity Liquid Chromatography-Mass Spectrometry of Peptides using Nanoflow Solvent Assisted Inlet Ionization. J. Am. Soc. Mass Spectrom. 23(3): 442–445, 2012. 

33)  Chubatyi, N.D., Wang, T., McEwen, C.N., More Inclusive or Selective Ionization for Mass Spectrometry using Obstructive Sonic Spray Ionization and Voltage Polarity Switching. Rapid Commun. Mass Spectrom. 26: 2763–2769, 2012.

34)  Lietz, C.B., Richards, A.L., Ren, Y., Trimpin, S., Inlet Ionization: Protein Analyses from the Solid State Without the Use of a Voltage or a Laser Producing up to 67 Charges on the 66 kDa BSA Protein. Rapid Commun. Mass Spectrom. 25(22): 3453–3456, 2011.

35)  Pagnotti, V.S., Inutan, E.D., Marshall, D.D., McEwen, C.N., Trimpin, S., Inlet Ionization:  A New Highly Sensitive Approach for Liquid Chromatography-Mass Spectrometry of Small and Large Molecules. Anal. Chem. 83(20): 7591–7594, 2011. 

36)  Pagnotti, V.S., Chubatyi, N.D., McEwen, C.N., Solvent Assisted Inlet Ionization: an Ultrasensitive New Liquid Introduction Ionization Method for Mass Spectrometry. Anal. Chem. 83:3981–3985, 2011.

37)  McEwen, C.N., Pagnotti, V., Inutan, E.D., Trimpin, S., New Paradigm in Ionization: Multiply Charged Ion Formation from a Solid Matrix without a Laser or Voltage. Anal. Chem. 82(22): 9164–9168, 2010. (Letters to Analytical Chemistry) 

38)  Trimpin, S., Wijerathne, K., McEwen, C.N., Rapid Methods of Polymer and Polymer Additives Identification: Multi-sample Solvent-free MALDI, Pyrolysis at Atmospheric Pressure, and Atmospheric Solids Analysis Probe Mass Spectrometry. Anal. Chim. Acta 654(1): 20–25, 2009. 

39)  Lloyd, J.A., Harron, A.F., McEwen, C.N., Combination Atmospheric Pressure Solids Analysis Probe and Desorption Electrospray Ionization Mass Spectrometry Ion Source. Anal. Chem. 81(21): 9158–9162, 2009.

40)  McEwen, C.N., Larsen, B.S., Ionization Mechanisms Related to Negative Ion APPI, APCI, and DART. J. Am. Soc. Mass Spectrom. 20(8): 1518–1521, 2009.

41)  McEwen, C.N., McKay, R.G., Larsen, B.S., Analysis of Solids, Liquids, and Biological Tissues using Solid Probe Introduction at Atmospheric Pressure on Commercial LC/MS Instruments. Anal. Chem. 77: 7826–7831, 2005.