The Ionique Manual Platform replaces the commercial ion source in seconds so that switching between the manual platform and the commercial source is fast and easy. The Ionique Manual Platform has capabilities of electrospray ionization (ESI), nano-electrospray (nESI) (optional), matrix-assisted ionization (MAI), solvent assisted ionization (SAI), and voltage-applied solvent assisted ionization (vSAI). Switching between ionization methods is also fast and simple. ESI, nESI, SAI and vSAI interface with an infusion pump or an LC with optimum flow rates between 4 – 60 microliters/minute. MAI offers sensitivity comparable to nESI but faster, easier, and more robust. The Ionique Manual Platform is a valuable and low-cost addition to any laboratory with interest in obtaining the most comprehensive analyses possible, or simply needing improved sensitivity.